Learn about the potential side effects of Zyprexa (olanzapine). Includes common and rare side effects information for consumers and healthcare professionals. Find information about common, infrequent and rare side effects of Zyprexa Oral. Learn about Numb Tongue from patients' first hand experiences and trusted online health resources, including common treatments and medications. 2,085 discussions on Treato Zyprexa is a serotonin-dopamine receptor blocker which is a kind of atypical anti-psychotic drug (drug for psychosis, psychiatric drug). Zyprexa is an atypical antipsychotic medication used to treat schizophrenia and manic episodes of bipolar disorder. Zyprexa available in generic form. 1. I've been taking Lamictal and Wellbutrin for about a year now and I've just recently noticed (past month or so) a few minutes after I take them, my tongue feels almost numb but not completely then goes back to normal. I was on Zyprexa for over 15 years after doctors had tried numerous anxiety/depression medicines without positive results. I was convinced that it was a bad drug and I should quit taking it a year ago even though I was happy and just newly married. Has anyone here ever gotten a numb tongue from taking Zyprexa, Risperdal or Seroquel? Whenever I take even low doses of any of these anti-psychotics my tongue gets real numb and tight feeling and my muscles get all tight and begin to pop and twitch mildly. Summary. Numbness and tingling is found among people who take Risperdal, especially for people who are male, 60+ old , have been taking the drug for 2 - 5 years, also take medication Zyprexa, and have Depression. Zyprexa: Olanzapine belongs to a group of medications known as antipsychotic/antimanic agents. Olanzapine is used to treat schizophrenia and related mental disorders, as well as bipolar disorder.